Macrophage Migration Inhibitory Factor Promotes Clearance of Pneumococcal Colonization

Colonization Promotes Clearance of Pneumococcal Macrophage Migration Inhibitory Factor

1677Macrophage migration inhibitory factor (MIF) promotes clearance of pneumococcal colonization

Background. Human genetic polymorphisms associated with decreased expression of macrophage migration inhibitory factor (MIF) have been linked to the risk of community-acquired pneumonia (CAP). Methods. Since Streptococcus pneumoniae is the leading cause of CAP and nasal carriage a precursor to invasive disease, we explored the role of MIF in the clearance of pneumococcal colonization in a mouse...

Macrophage Migration Inhibitory Factor

Glucocorticoid Suppression of Macrophage Migration Inhibitory Factor

The ability of hydrocortisone to modify antigen-mediated inhibition of macrophage migration, an in vitro correlate of cellular immunity in the guinea pig, was investigated. Only the glucocorticoids, hydrocortisone and dexamethasone, significantly blocked migration inhibitory factor (MIF) activity in pharmacologic concentrations. Hydrocortisone had no effect on antigen "processing" by macrophage...

Correlation between urine macrophage migration inhibitory factor (MIF)/creatinine ratio and time after kidney transplantation

 Abstract  Background: Despite the long-standing association of macrophage migration inhibitory  factor (MIF) with delayed-type hypersensitivity response, the potential role  of MIF in chronic allograft nephropathy is unknown. The association between upregulation of MIF expression, macrophage and T cell infiltration and the severity of  chronic allograft nephropathy suggests that MIF may be an ...